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Combined with the fact that semaglutide already has approval for use in Type 2 diabetes mellitus and a good safety record, there is potential for semaglutide and other GLP-1R agonists to be repurposed as neuroprotective therapeutic agents

Hippocampal neurons were maintained in Neurobasal A media from Invitrogen (Carlsbad, CA) supplemented with B27 from Invitrogen 0.5 mM L-glutamine, and 5mM cytosme-D-arabinofuranoside from Sigma added at 2 days in vitro